Registration No. 333-50340



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933



                           ORASURE TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                        36-4370966
  (State of incorporation)                     (IRS Employer Identification No.)

        150 Webster Street
        Bethlehem, Pennsylania                              18015
(Address of principal executive offices)                  (Zip Code)


                ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN
                  ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE
                       AND NON-QUALIFIED STOCK OPTION PLAN
                       EPITOPE, INC. 1991 STOCK AWARD PLAN
                            (Full title of the plan)


                               Robert D. Thompson
                             Chief Executive Officer
                           OraSure Technologies, Inc.
                               150 Webster Street
                          Bethlehem, Pennsylvania 18015
                            Telephone (610) 882-1820
           (Name, address, and telephone number of agent for service)


================================================================================

This post-effective amendment No. 1 to registration statement on Form S-8 (file no. 333-50340) is being filed to add a plan title to the cover page, which was inadvertently omitted from the original filing. The opinion of counsel and power of attorney are also being revised to include reference to the additional plan. No other changes are being made to the original filing and the number of registered shares remains the same. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this post-effective amendment No. 1 to registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Bethlehem, commonwealth of Pennsylvania, on the 27th of June, 2001. OraSure Technologies, Inc. (Registrant) By /s/Robert D. Thompson ------------------------ Robert D. Thompson Chief Executive Officer Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated as of the 27th day of June, 2001. Signature Title (1) Principal Executive Officer /s/ Robert D. Thompson - ----------------------------- Robert D. Thompson Chief Executive Officer and Director (2) Principal Financial Officer /s/ Richard D. Hooper - ----------------------------- Richard D. Hooper Vice President,Finance and Chief Financial Officer (3) Principal Accounting Officer /s/ Mark L. Kuna - ----------------------------- Mark L. Kuna Controller (4) A majority of the Board of Directors * MICHAEL J. GAUSLING President, Chief Operating Officer and Director * FRANK G. HAUSMANN, JR. Director * MICHAEL G. BOLTON Director * WILLIAM W. CROUSE Director * ROGER L. PRINGLE Director * By /s/ Robert D. Thompson ------------------------------ Robert D. Thompson Attorney-in-fact

INDEX TO EXHIBITS 4.1 Certificate of Incorporation of the registrant. Incorporated by reference to Exhibit 3.1 to the registrant's Registration Statement on Form S-4 (File No. 333-39210) ("Form S-4"). 4.1.1 Certificate of Amendment to Certificate of Incorporation dated May 23, 2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4. 4.2 Bylaws of the registrant. Incorporated by reference to Exhibit 3.2 to Form S-4. 4.3 Rights Agreement dated as of May 6, 2000, between the registrant and ChaseMellon Shareholder Services, L.L.C. Incorporated by reference to Exhibit 4.2 to Form S-4. 5 Opinion of Miller Nash LLP. 23.1 Consent of PricewaterhouseCoopers LLP.* 23.2 Consent of Arthur Andersen LLP.* 23.3 Consent of Miller Nash LLP. Included in Exhibit 5. 24 Power of attorney of certain officers and directors. *Previously filed Other exhibits listed in Item 601 to Regulation S-K are not applicable.

                                    Exhibit 5

                                 MILLER NASH LLP
                             3500 U.S. Bancorp Tower
                              111 S.W. Fifth Avenue
                           Portland, Oregon 97204-3699

                                June 27, 2001


OraSure Technologies, Inc.
150 Webster Street
Bethlehem, Pennsylvania 18015


            Subject:    OraSure Technologies, Inc., Registration
                        Statement on Form S-8
Ladies and Gentlemen:

            Reference  is  made  to  post-effective   amendment  No.  1  to  the
registration  statement on Form S-8  ("Registration  Statement")  to be filed by
OraSure  Technologies,  Inc., a Delaware  corporation (the "Company"),  with the
Securities and Exchange  Commission for the purpose of amending the registration
statement with respect to the registration  under the Securities Act of 1933, as
amended,  of 6,185,400 shares (the "Registered  Shares") of the Company's common
stock,  $.000001 per share ("Common Stock"), to be issued in connection with the
Company's  2000 Stock Award Plan and its Employee  Incentive  and  Non-Qualified
Stock Option Plan and the Epitope, Inc. 1991 Stock Award Plan (collectively, the
"Plans"), together with options and other rights related thereto. Epitope, Inc.,
is a  predecessor  to the  Company,  which was merged  with and into the Company
effective September 29, 2000.

            We  have  examined  originals  or  copies,  certified  or  otherwise
identified to our  satisfaction,  of such  corporate  records,  certificates  of
public officials, and other documents as we have deemed necessary or relevant as
a basis for the opinion set forth herein.

            Based  on the  foregoing,  it is our  opinion  that  the  Registered
Shares,  when sold and  delivered  by the  Company  upon  exercise of options or
pursuant to other rights duly granted under the Plans  against  payment for such
shares to the extent and in the manner  required  by the Plans,  will be validly
issued, fully paid and non-assessable.

            We consent to the use of this opinion in the Registration  Statement
and in any amendments thereof.

                                Very truly yours,

                                /s/   MILLER NASH LLP

                                   Exhibit 24

                                POWER OF ATTORNEY

      Each person whose signature  appears below constitutes and appoints Robert
D.  Thompson and Jack E. Jerrett,  and each of them,  his or her true and lawful
attorneys-in-fact  and agents,  with full power of substitution,  in any and all
capacities,  to sign a registration statement on Form S-8 to be filed by OraSure
Technologies,  Inc.,  relating  to  6,185,400  shares of its common  stock to be
issued pursuant to the OraSure Technologies,  Inc. 2000 Stock Award Plan and the
OraSure  Technologies,  Inc. Employee  Incentive and Non-Qualified  Stock Option
Plan, and pursuant to options  previously  granted under the Epitope,  Inc. 1991
Stock  Award  Plan  and  any  and  all  amendments   (including   post-effective
amendments) to such registration statement, and to file the same, with exhibits,
with the Securities and Exchange Commission. In addition, the undersigned grants
unto  said  attorneys-in-fact  and  agents,  and each of them,  full  power  and
authority to do and perform  each and every act  requisite  and  necessary to be
done,  as fully to all intents  and  purposes as he might or could do in person,
hereby ratifying and confirming all that said  attorneys-in-fact  and agents may
lawfully do or cause to be done.

      IN  WITNESS  WHEREOF,  this  power  of  attorney  has been  signed  by the
following persons in the capacities indicated as of October 31, 2000.


/s/ Robert D. Thompson                   Chief Executive Officer and Director
- ---------------------------------
Robert D. Thompson

/s/ Michael G. Bolton                    Director
- ---------------------------------
Michael G. Bolton

/s/ William W. Crouse                    Director
- ---------------------------------
William W. Crouse

/s/ Michael J. Gausling                  President, Chief Operating Officer and
- ---------------------------------        Director
Michael J. Gausling

/s/ Frank G. Hausmann                    Director
- ---------------------------------
Frank G. Hausmann

/s/ Roger L. Pringle                     Director
- ---------------------------------
Roger L. Pringle