SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                    FORM 8-K
                                 CURRENT REPORT

                         PURSUANT TO SECTION 13 OR 15(D)
                     OF THE SECURITIES EXCHANGE ACT OF 1934




        Date of Report (Date of earliest event reported): March 30, 2001

                           ORASURE TECHNOLOGIES, INC.
                           --------------------------
               (Exact name of registrant as specified in charter)



       DELAWARE                    1-10492                    36-4370966
    (State or Other              (Commission              (I.R.S. Employer
     Jurisdiction                    file                   Identification
  of Incorporation or               number)                    Number)
     Organization)



                               150 WEBSTER STREET
                        BETHLEHEM, PENNSYLVANIA 18015
                   (Address of principal executive offices)


                                (610) 882-1820
             (Registrant's telephone number, including area code)









ITEM 4. CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT

As  previously  disclosed in its Current  Report on Form 8-K dated  December 18,
2000,  OraSure  Technologies,  Inc. (the "Company") (i) informed its independent
accountants,  PricewaterhouseCoopers  LLP ("PWC"),  that they would be dismissed
upon  completion of their audit of the Company's  financial  statements  for the
three-month transition period ended December 31, 1999 (the "Transition Period"),
and (ii) retained Arthur Andersen LLP as its independent  accountants  effective
such date. On March 26, 2001, PWC completed the audit of the  Transition  Period
and is no longer providing services for the Company.

The  report of PWC on the  Company's  financial  statements  for the  Transition
Period did not contain an adverse opinion or a disclaimer of opinion and was not
qualified or modified as to uncertainty,  audit scope or accounting  principles.
During its audit of the Transition  Period, (i) there were no disagreements with
PWC on any matter of accounting  principles or  practices,  financial  statement
disclosure or auditing scope or procedure, which disagreements,  if not resolved
to PWC's  satisfaction,  would have caused PWC to make  reference to the subject
matter of such  disagreements in their report, and (ii) there were no reportable
events as defined in Item 304(a)(1)(v) of Regulation S-K.

Pursuant to Item  304(a)(3)  of  Regulation  S-K, the Company  requested  PWC to
furnish it a letter addressed to the Securities and Exchange  Commission stating
whether it agrees with the above  statements.  A copy of that letter is filed as
an Exhibit to this Form 8-K.

ITEM 7.     FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS

            Exhibit
            16          Letter from PWC dated March 30, 2001.





                                   SIGNATURES

      Pursuant to the  requirements of the Securities  Exchange Act of 1934, the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned, hereunto duly authorized.


                                    ORASURE TECHNOLOGIES, INC.


Date: March 30, 2001                      By: /s/Robert D. Thompson
                                              ------------------
                                              Robert D. Thompson
                                              Chief Executive Officer








                                Index to Exhibits

            Exhibit
            -------
            16        Letter   from   PWC   to   the   Company    dated
                      March 30, 2001.



EXHIBIT 16


March 30, 2001


Securities and Exchange Commission
450 Fifth Street, NW
Washington, D.C. 20549


Commissioners:

            We have read the statements made by OraSure Technologies,  Inc. (the
Company) (copy attached), which we understand will be filed with the Commission,
pursuant to Item 4 of Form 8-K, as part of the  Company's  Form 8-K report dated
March 30, 2001. We agree with the  statements  concerning  our Firm in such Form
8-K.

Very truly yours,

/s/ PricewaterhouseCoopers LLP

PricewaterhouseCoopers LLP