Registration No. 333-50340



                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                         POST-EFFECTIVE AMENDMENT NO. 2
                                       TO
                                    FORM S-8

                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933



                           ORASURE TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

          Delaware                                         36-4370966
  (State of incorporation)                     (IRS Employer Identification No.)

       150 Webster Street
       Bethlehem, Pennsylania                                18015
(Address of principal executive offices)                   (Zip Code)


                  ORASURE TECHNOLOGIES, INC. 2000 STOCK AWARD PLAN
                  ORASURE TECHNOLOGIES, INC. EMPLOYEE INCENTIVE
                     AND NON-QUALIFIED STOCK OPTION PLAN
                  EPITOPE, INC. 1991 STOCK AWARD PLAN
                  NONQUALIFIED STOCK OPTION AGREEMENT FOR
                     DISCOUNTED NON-PLAN OPTION GRANTED TO
                     ROBERT D. THOMPSON
                  AGRITOPE, INC. 1992 STOCK AWARD PLAN
                           (Full titles of the plans)


                                 Jack E. Jerrett
                       Vice President and General Counsel
                           OraSure Technologies, Inc.
                               150 Webster Street
                          Bethlehem, Pennsylvania 18015
                            Telephone (610) 882-1820
           (Name, address, and telephone number of agent for service)





This post-effective amendment No. 2 to registration statement on Form S-8 (file no. 333-50340) is being filed to add plan titles to the cover page, which were inadvertently omitted from the original filing. The opinion of counsel and power of attorney are also being revised to include reference to the additional plans. No other changes are being made to the original filing and the number of registered shares remains the same. SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this post-effective amendment No. 2 to registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Bethlehem, state of Pennsylvania, on the 12th of February, 2002. OraSure Technologies, Inc. (Registrant) By /s/ Michael J. Gausling ------------------------------------- Michael J. Gausling Chief Executive Officer and President Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated as of the 12th day of February, 2002. Signature Title (1) Principal Executive Officer /s/ Michael J. Gausling -------------------------------- Michael J. Gausling Chief Executive Officer, President and Director (2) Principal Financial Officer /s/ Ronald H. Spair -------------------------------- Ronald H. Spair Executive Vice President and Chief Financial Officer (3) Principal Accounting Officer /s/ Mark L. Kuna -------------------------------- Mark L. Kuna Controller (4) A majority of the Board of Directors * FRANK G. HAUSMANN Director * MICHAEL G. BOLTON Director * WILLIAM W. CROUSE Director * ROGER L. PRINGLE Director * CARTER H. ECKERT Director * By /s/ Michael J. Gausling -------------------------------- Michael J. Gausling Attorney-in-fact

INDEX TO EXHIBITS 4.1 Certificate of Incorporation of the registrant. Incorporated by reference to Exhibit 3.1 to the registrant's Registration Statement on Form S-4 (File No. 333-39210) ("Form S-4"). 4.1.1 Certificate of Amendment to Certificate of Incorporation dated May 23, 2000. Incorporated by reference to Exhibit 3.1.1 to Form S-4. 4.2 Amended and Restated Bylaws of the registrant. Incorporated by reference to Exhibit 10 to registrant's Quarterly Report on Form 10-Q for the quarter ended September 30, 2001. 4.3 Rights Agreement dated as of May 6, 2000, between the registrant and ChaseMellon Shareholder Services, L.L.C. Incorporated by reference to Exhibit 4.2 to Form S-4. 5 Opinion of Miller Nash LLP. 23.1 Consent of PricewaterhouseCoopers LLP.* 23.2 Consent of Arthur Andersen LLP.* 23.3 Consent of Miller Nash LLP. Included in Exhibit 5. 24 Power of attorney of certain officers and directors. *Previously filed Other exhibits listed in Item 601 to Regulation S-K are not applicable.

                                   Exhibit 5

                                 MILLER NASH LLP
                             3500 U.S. Bancorp Tower
                              111 S.W. Fifth Avenue
                           Portland, Oregon 97204-3699



                               February 12, 2002



OraSure Technologies, Inc.
150 Webster Street
Bethlehem, Pennsylvania  18015

            Subject:    OraSure Technologies, Inc., Registration
                        Statement on Form S-8
Ladies and Gentlemen:

            Reference  is  made  to  post-effective   amendment  No.  2  to  the
registration  statement on Form S-8  ("Registration  Statement")  to be filed by
OraSure  Technologies,  Inc., a Delaware  corporation (the "Company"),  with the
Securities and Exchange  Commission for the purpose of amending the registration
statement with respect to the registration  under the Securities Act of 1933, as
amended,  of 6,185,400 shares (the "Registered  Shares") of the Company's common
stock,  $.000001 per share  ("Common  Stock"),  to be issued under the Company's
2000 Stock Award Plan and its Employee Incentive and Non-Qualified  Stock Option
Plan,  the Epitope,  Inc. 1991 Stock Award Plan, the  Nonqualified  Stock Option
Agreement for Discounted Non-Plan Option granted to Robert D. Thompson,  and the
Agritope, Inc. 1992 Stock Award Plan (collectively,  the "Plans"), together with
options and other rights related thereto. Epitope, Inc., is a predecessor to the
Company,  which was merged with and into the  Company  effective  September  29,
2000.  Agritope,  Inc. was a subsidiary of Epitope until December 29, 2000, when
all the capital stock of Agritope was distributed to Epitope's shareholders in a
spin-off transaction.

            We  have  examined  originals  or  copies,  certified  or  otherwise
identified to our  satisfaction,  of such  corporate  records,  certificates  of
public officials, and other documents as we have deemed necessary or relevant as
a basis for the opinion set forth herein.



Based on the foregoing, it is our opinion that the Registered Shares, when sold and delivered by the Company upon exercise of options or pursuant to other rights duly granted under the Plans against payment for such shares to the extent and in the manner required by the Plans, will be validly issued, fully paid and non-assessable. We consent to the use of this opinion in the Registration Statement and in any amendments thereof. Very truly yours, /s/ MILLER NASH LLP

                                   Exhibit 24


                                POWER OF ATTORNEY


      Each person whose signature appears below constitutes and appoints Michael
J.  Gausling and Jack E. Jerrett,  and each of them,  his or her true and lawful
attorneys-in-fact  and agents,  with full power of substitution,  in any and all
capacities,  to sign a registration statement on Form S-8 to be filed by OraSure
Technologies,  Inc.,  relating  to  6,185,400  shares of its common  stock to be
issued  pursuant to the OraSure  Technologies,  Inc. 2000 Stock Award Plan,  the
OraSure  Technologies,  Inc. Employee  Incentive and Non-Qualified  Stock Option
Plan,  the Epitope,  Inc. 1991 Stock Award Plan, the  Nonqualified  Stock Option
Agreement for  Discounted  Plan Option  Granted to Robert D.  Thompson,  and the
Agritope,  Inc.  1992 Stock Award Plan,  and any and all  amendments  (including
post-effective amendments) to such registration statement, and to file the same,
with exhibits,  with the Securities and Exchange  Commission.  In addition,  the
undersigned  grants unto said  attorneys-in-fact  and agents,  and each of them,
full power and  authority  to do and perform  each and every act  requisite  and
necessary to be done,  as fully to all intents and purposes as he might or could
do in person,  hereby  ratifying and confirming all that said  attorneys-in-fact
and agents may lawfully do or cause to be done.

      IN  WITNESS  WHEREOF,  this  power  of  attorney  has been  signed  by the
following persons in the capacities indicated as of February 12, 2002.


/s/ Michael J. Gausling
- ------------------------            Chief Executive Officer, President and
Michael J. Gausling                 Director

/s/ Michael G. Bolton               Director
- ------------------------
Michael G. Bolton

/s/ William W. Crouse               Director
- ------------------------
William W. Crouse

/s/ Carter H. Eckert                Director
- ------------------------
Carter H. Eckert

/s/ Frank G. Hausmann               Director
- ------------------------
Frank G. Hausmann

/s/ Roger L. Pringle                Director
- ------------------------
Roger L. Pringle

                                    Director
- ------------------------
Gregory B. Lawless