SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G
                                  Rule 13d-102

                    Under the Securities Exchange Act of 1934
                               (Amendment No.  )*

                           ORASURE TECHNOLOGIES, INC.
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                        Common Stock, $.000001 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)


- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                               September 29, 2000
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

      Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:

                               |_| Rule 13d-1 (b)
                               |X| Rule 13d-1 (c)
                               |_| Rule 13d-1 (d)

- ----------
*     The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which
would alter disclosures provided in a prior cover page.

      The information required on the remainder of this cover page shall not be
deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934 ("Act") or otherwise subject to the liabilities of that section of
the Act but shall be subject to all other provisions of the Act (however, see
the Notes).


                                                                    Page 1 of 16

CUSIP No. 68554V 10 8 13G Page 2 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Ventures V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 3 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON HealthCare Partners V, L.P. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Delaware - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* PN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 4 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON James H. Cavanaugh, Ph.D. - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 5 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Harold Werner - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 6 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON William Crouse - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER 7,944 -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON 7,944 WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,123,242 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.59% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 7 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON John Littlechild - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 8 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Christopher Mirabelli - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

CUSIP No. 68554V 10 8 13G Page 9 of 16 - -------------------------------------------------------------------------------- 1 NAME OF REPORTING PERSON S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON Augustine Lawlor - -------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) |_| (b) |_| - -------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------- 5 SOLE VOTING POWER -------------------------------------------------------------- NUMBER OF 6 SHARED VOTING POWER SHARES BENEFICIALLY 3,115,298 OWNED BY -------------------------------------------------------------- EACH 7 SOLE DISPOSITIVE POWER REPORTING PERSON WITH -------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 3,115,298 - -------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,115,298 - -------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* |_| - -------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 8.57% - -------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON* IN - -------------------------------------------------------------------------------- *SEE INSTRUCTIONS BEFORE FILLING OUT

Page 10 of 16 Item 1. (a) Name of Issuer: Orasure Technologies Inc. (b) Address of Issuer's Principal Executive Offices: 8505 S.W. Creekside Place Beaverton, Oregon 97008 Item 2. (a) Name of Person Filing: HealthCare Ventures V, L.P. ("HCV V"), HealthCare Partners V, L.P. ("HCP V"), Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse, Mirabelli and Lawlor. See attached Exhibit A which is a copy of their agreement in writing to file this statement on behalf of each of them.1 (b) Address of Principal Business Office or, if none, Residence: The business address for HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New Jersey 08542. The business address for Messrs. Littlechild, Mirabelli and Lawlor is One Kendall Square, Building 300, Cambridge, Massachusetts 02139. (c) Citizenship: HCV V and HCP V are limited partnerships organized under the laws of the State of Delaware. Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse, Mirabelli and Lawlor are each United States citizens. (d) Title of Class of Securities: Common Stock, $.000001 par value per share. (e) CUSIP Number: 68554V 10 8 - -------- 1 Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse, Mirabelli and Lawlor are general partners of HCP V, which is the General Partner of HCV V, the record holder of the Issuer's Common Stock reported hereto.

Page 11 of 16 Item 3. If this statement if filed pursuant to ss.ss.240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a: Inapplicable. Item 4. Ownership. (a) Amount beneficially owned: As of September 29, 2000, HCV V and HCP V beneficially owned 3,115,298 shares of the Issuer's Common Stock; Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse, Mirabelli and Lawlor each beneficially owned 3,115,298 shares of the Issuer's Common Stock. In addition, Mr. Crouse beneficially owned immediately exercisable options to purchase 7,944 shares of the Issuer's Common Stock at a price of $.80249 per share. (b) Percent of Class: As of September 29, 2000, the 3,115,298 shares of the Issuer's Securities beneficially owned by each of HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Mirabelli and Lawlor constitute 8.57% of the Issuer's Common Stock outstanding; the 3,123,242 shares of the Issuer's Common Stock beneficially owned by Mr. Crouse constitutes 8.59% of the Issuer's shares of Common Stock outstanding. (c) Number of shares as to which such person has: (i) sole voting power or to direct the vote: Mr. Crouse has the sole power to vote or direct the vote of the 7,944 shares of the Issuer's Common Stock beneficially owned by him. (ii) shared power to vote or to direct the vote: HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Mirabelli and Lawlor share the power to vote or direct the vote of those shares of Common Stock owned by HCV V.

Page 12 of 16 Item. 4 (continued): (iii) sole power to dispose or to direct the disposition of: Mr. Crouse has the sole power to vote or direct the vote of the 7,944 shares of the Issuer's Common Stock beneficially owned by him. (iv) shared power to dispose of or to direct the disposition of: HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse, Mirabelli and Lawlor share the power to vote or direct the vote of those shares of Common Stock owned by HCV V. Item 5. Ownership of Five Percent or less of a Class: Inapplicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person: Inapplicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company: Inapplicable. Item 8. Identification and Classification of Members of the Group: Inapplicable. Item 9. Notice of Dissolution of Group: Inapplicable. Item 10. Certification: By signing below, I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

Page 13 of 16 SIGNATURES After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Dated: October 4, 2000 HealthCare Ventures V, L.P. Princeton, New Jersey by: its General Partner, HealthCare Partners V, L.P. By: s/ Jeffrey Steinberg ----------------------------------------- Jeffrey Steinberg, Administrative Partner Dated: October 4, 2000 HealthCare Partners V, L.P. Princeton, New Jersey By: s/ Jeffrey Steinberg, Attorney-in-Fact ----------------------------------------- Jeffrey Steinberg Administrative Partner Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- James H. Cavanaugh, Ph.D Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- Harold R. Werner Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- John W. Littlechild Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- William Crouse

Page 14 of 16 Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Christopher Mirabelli Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Augustine Lawlor


                                                                   Page 15 of 16


                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13G

      The undersigned hereby agree to jointly prepare and file with the
regulatory authorities a Schedule 13G and any future amendments thereto
reporting each of the undersigned's ownership of securities of OraSure
Technologies, Inc. and hereby affirm that such Schedule 13G is being filed on
behalf of each of the undersigned.

Dated: October 4, 2000              HealthCare Ventures V, L.P.
       Princeton, New Jersey        by: its General Partner, HealthCare Partners
                                    V, L.P.

                                    By: s/ Jeffrey Steinberg
                                       -----------------------------------------
                                          Jeffrey Steinberg,
                                          Administrative Partner


Dated: October 4, 2000              HealthCare Partners V, L.P.
       Princeton, New Jersey

                                    By: s/ Jeffrey Steinberg, Attorney-in-Fact
                                       -----------------------------------------
                                           Jeffrey Steinberg
                                           Administrative Partner

Dated: October 4, 2000                  s/ Jeffrey Steinberg, Attorney-in-Fact
       Princeton, New Jersey        --------------------------------------------
                                           James H. Cavanaugh, Ph.D


Dated: October 4, 2000                 s/ Jeffrey Steinberg, Attorney-in-Fact
       Princeton, New Jersey        --------------------------------------------
                                          Harold R. Werner


Dated: October 4, 2000                 s/ Jeffrey Steinberg, Attorney-in-Fact
       Cambridge, Massachusetts     --------------------------------------------
                                          John W. Littlechild

Page 16 of 16 Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- William Crouse Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Christopher Mirabelli Dated: October 4, 2000 s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Augustine Lawlor