UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

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                                  SCHEDULE 13G

                  Under the Securities and Exchange Act of 1934

                                (Amendment No.2)*

                           ORASURE TECHNOLOGIES, INC.

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                                (Name of Issuer)

                        Common Stock, $.000001 par value

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                         (Title of Class of Securities)

                                   68554V 10 8

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                                 (CUSIP Number)

                                December 31, 2002

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             (Date of Event Which Requires Filing of this Statement)


     Check the  appropriate  box to  designate  the rule  pursuant to which this
Schedule is filed:

          [_]  Rule 13d-1(b)

          [x]  Rule 13d-1(c)

          [ ]  Rule 13d-1(d)


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*    The  remainder  of this  cover  page  shall be filled  out for a  reporting
     person's  initial  filing on this form with respect to the subject class of
     securities,  and for any subsequent amendment containing  information which
     would alter the disclosures provided in a prior cover page.

     The  information  required in the remainder of this cover page shall not be
deemed to be "filed"  for the purpose of Section 18 of the  Securities  Exchange
Act of 1934 or otherwise  subject to the  liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

CUSIP No. 68554V 10 8 13G Page 2 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) HealthCare Ventures V, L.P. ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* PN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 3 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) HealthCare Partners V, L.P. ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION Delaware ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* PN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 4 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) James H. Cavanaugh, Ph.D. ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 5 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Harold R. Werner ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES 7,944 _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING 7,944 _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,941,151 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.83% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 6 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) William Crouse ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES 97,111 _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING 97,111 _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,030,318 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 8.07% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 7 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) John W. Littlechild ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 8 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Christopher Mirabelli, Ph.D. ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 9 of 15 Pages ________________________________________________________________________________ 1. NAME OF REPORTING PERSONS I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY) Augustine Lawlor ________________________________________________________________________________ 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP* (a) [_] (b) [_] ________________________________________________________________________________ 3. SEC USE ONLY ________________________________________________________________________________ 4. CITIZENSHIP OR PLACE OF ORGANIZATION United States ________________________________________________________________________________ NUMBER OF 5. SOLE VOTING POWER SHARES _________________________________________________________________ BENEFICIALLY 6. SHARED VOTING POWER OWNED BY 2,933,207 _________________________________________________________________ EACH 7. SOLE DISPOSITIVE POWER REPORTING _________________________________________________________________ PERSON 8. SHARED DISPOSITIVE POWER WITH 2,933,207 ________________________________________________________________________________ 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 2,933,207 ________________________________________________________________________________ 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES* [_] ________________________________________________________________________________ 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 7.81% ________________________________________________________________________________ 12. TYPE OF REPORTING PERSON* IN ________________________________________________________________________________ *SEE INSTRUCTIONS BEFORE FILLING OUT!

CUSIP No. 68554V 10 8 13G Page 10 of 15 Pages Item 1(a). Name of Issuer: Orasure Technologies, Inc. ____________________________________________________________________ Item 1(b). Address of Issuer's Principal Executive Offices: 150 Webster Street Bethlehem, PA 18015 ____________________________________________________________________ Item 2(a). Name of Person Filing: HealthCare Ventures V, L.P. ("HCV V"), HealthCare Partners V, L.P. ("HCP V"), Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse and Lawlor. See attached Exhibit A, which is a copy of their agreement in writing to file this statement on behalf of each of them.(1) ____________________________________________________________________ Item 2(b). Address of Principal Business Office, or if None, Residence: The business address for HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street, Princeton, New Jersey 08542. The business address for Dr. Mirabelli and Messrs. Littlechild and Lawlor is One Kendall Square, Building 300, Cambridge, Massachusetts 02339. ____________________________________________________________________ Item 2(c). Citizenship: HCV V, and HCP V are limited partnerships organized under the laws of the State of Delaware. Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse and Lawlor are each United States citizens. ____________________________________________________________________ Item 2(d). Title of Class of Securities: Common Stock par value $.000001 (the "Shares") ______________________________________________________________ (1) Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse and Lawlor are general partners of HCP V, the general partner of HCV V, the record holder of the Issuer's Common Stock reported hereto.

CUSIP No. 68554V 10 8 13G Page 11 of 15 Pages Item 2(e). CUSIP Number: 68554V 10 8 ____________________________________________________________________ Item 3. If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a: Not Applicable (a) [_] Broker or dealer registered under Section 15 of the Exchange Act. (b) [_] Bank as defined in Section 3(a)(6) of the Exchange Act. (c) [_] Insurance company as defined in Section 3(a)(19) of the Exchange Act. (d) [_] Investment company registered under Section 8 of the Investment Company Act. (e) [_] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E); (f) [_] An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F); (g) [_] A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G); (h) [_] A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act; (i) [_] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act; (j) [_] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

CUSIP No. 68554V 10 8 13G Page 12 of 15 Pages Item 4. Ownership. Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1. (a) Amount beneficially owned: As of December 31, 2002: HCV V and HCP V beneficially owned 2,933,207 Shares of the Issuer's Common Stock; Drs. Cavanaugh and Mirabelli and Messrs. Littlechild and Lawlor each beneficially owned 2,933,207 Shares; Mr. Crouse beneficially owned 3,030,318 Shares consisting of 2,933,207 Shares of the Issuer's Common Stock and options to purchase 97,111 Shares of the Issuer's Common Stock(2); Mr. Werner beneficially owned 2,941,151 Shares consisting of 2,933,207 of the Issuer's Common Stock and options to purchase 7,944 Shares of the Issuer's Common Stock. ______________________________________________________________ (b) Percent of class: As of December 31, 2002: the 2,933,207 Shares beneficially owned by HCV V and HCP V constitutes 7.81% of the Shares outstanding; the 2,933,207 Shares beneficially owned by Drs. Cavanaugh and Mirabelli and Messrs. Littlechild and Lawlor constitutes 7.81% of the Shares outstanding; the 3,030,318 Shares beneficially owned by Mr. Crouse constitute 8.07% of the Shares outstanding; and the 2,941,151 Shares beneficially owned by Mr. Werner constitutes 7.83% of the Shares outstanding. ______________________________________________________________ (2) Does not include options to purchase an additional 30,833 Shares of the Issuer's Common Stock which were granted to Mr. Crouse as a director of the Issuer and which are not currently exercisable within 60 days of 12/31/02. 3,333 of these options become exercisable as to 1,666.66 Shares per month for 2 months beginning on March 17, 2003, and 27,500 of these options become exercisable as to 2,500 shares per month for 11 months beginning on March 30, 2003. (Mr. Crouse is not deemed to beneficially own these Shares at the date of this report.)

CUSIP No. 68554V 10 8 13G Page 13 of 15 Pages (c) Number of shares as to which such person has: (i) Sole power to vote or to direct the vote: Mr. Crouse has the sole power to vote or direct the vote as to the 97,111 Shares of the Issuer's Common Stock beneficially owned by him. Mr. Werner has the sole power to vote or direct the vote as to the 7,944 Shares of the Issuer's Common Stock beneficially owned by him. (ii) Shared power to vote or to direct the vote: HCV V, HCP V, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse and Lawlor share the power to vote or direct the vote of those Shares owned by HCV V. (iii) Sole power to dispose or to direct the disposition of: Mr. Crouse has the sole power to dispose of or to direct the disposition of the 97,111 Shares of the Issuer's Common Stock beneficially owned by him. Mr. Werner has the sole power to dispose of or to direct the disposition of the 7,944 Shares of the Issuer's Common Stock beneficially owned by him. (iv) Shared power to dispose or to direct the disposition of: HCV V, HCP V, Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild, Crouse and Lawlor share the power to dispose of or direct the disposition of those Shares owned by HCV V.

CUSIP No. 68554V 10 8 13G Page 14 of 15 Pages Item 5. Ownership of Five Percent or Less of a Class. If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities check the following [ ]. Not Applicable _______________________________________________________________________ Item 6. Ownership of More Than Five Percent on Behalf of Another Person. Not Applicable. _______________________________________________________________________ Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. Not Applicable. _______________________________________________________________________ Item 8. Identification and Classification of Members of the Group. Not Applicable. _______________________________________________________________________ Item 9. Notice of Dissolution of Group. Not Applicable. ______________________________________________________________________ Item 10. Certifications. By signing below, I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

CUSIP No. 68554V 10 8 13G Page 15 of 15 Pages SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. February 3, 2003 HealthCare Ventures V, L.P. Princeton, New Jersey By: its General Partner, HealthCare Partners V, L.P. By: /s/ Jeffrey Steinberg -------------------------------------------- Jeffrey Steinberg, Administrative Partner February 3, 2003 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------------------- Jeffrey Steinberg, Administrative Partner February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- James H. Cavanaugh, Ph.D February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- Harold Werner February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- William Crouse February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- John W. Littlechild February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Christopher Mirabelli, Ph.D. February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Augustine Lawlor

EXHIBIT A AGREEMENT JOINT FILING OF SCHEDULE 13G The undersigned hereby agree to jointly prepare and file with regulatory authorities a Schedule 13G and any future amendments thereto reporting each of the undersigned's ownership of securities of Orasure Technologies, Inc. Corporation and hereby affirm that such Schedule 13G is being filed on behalf of each of the undersigned. February 3, 2003 HealthCare Ventures V, L.P. Princeton, New Jersey By: its General Partner, HealthCare Partners V, L.P. By: /s/ Jeffrey Steinberg -------------------------------------------- Jeffrey Steinberg, Administrative Partner February 3, 2003 HealthCare Partners V, L.P. Princeton, New Jersey By: /s/ Jeffrey Steinberg -------------------------------------------- Jeffrey Steinberg, Administrative Partner February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- James H. Cavanaugh, Ph.D February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- Harold Werner February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Princeton, New Jersey -------------------------------------------- William Crouse February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- John W. Littlechild February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Christopher Mirabelli, Ph.D. February 3, 2003 /s/ Jeffrey Steinberg, Attorney-in-Fact Cambridge, Massachusetts -------------------------------------------- Augustine Lawlor Note. Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties for whom copies are to be sent. Attention. Intentional misstatements or omissions of fact constitute federal criminal violations (see 18 U.S.C. 1001).