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<!-- Creation Date :2023-03-03T16:58:08.8243+00:00 -->
<!-- Copyright (c) 2023 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="osur_CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" name="CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_DisclosureLeasesScheduleOfMinimumLeasePaymentsByPeriodExpectedDetailAbstract" name="DisclosureLeasesScheduleOfMinimumLeasePaymentsByPeriodExpectedDetailAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_FinanceLeaseAbstract" name="FinanceLeaseAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_FinanceLeaseCost1Abstract" name="FinanceLeaseCost1Abstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_NonCashActivityAbstract" name="NonCashActivityAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_TransitionCostsAbstract" name="TransitionCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_WeightedAverageDiscountRateAbstract" name="WeightedAverageDiscountRateAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_WeightedAverageRemainingLeaseTermAbstract" name="WeightedAverageRemainingLeaseTermAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_AccruedExpensesAndOtherCurrentLiabilities" name="AccruedExpensesAndOtherCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_AllocatedShareBasedCompensationExpenseAmountsCapitalizedIntoInventory" name="AllocatedShareBasedCompensationExpenseAmountsCapitalizedIntoInventory" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_AllocatedShareBasedCompensationExpenseCostOfSales" name="AllocatedShareBasedCompensationExpenseCostOfSales" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_BusinessCombinationContingentConsiderationExpectedPaymentPeriod" name="BusinessCombinationContingentConsiderationExpectedPaymentPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_BusinessCombinationContingentConsiderationExpectedPaymentYear" name="BusinessCombinationContingentConsiderationExpectedPaymentYear" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_BusinessCombinationContingentConsiderationPayments" name="BusinessCombinationContingentConsiderationPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_Businesscombinationrecognizedidentifiableassetsacquiredgoodwillandliabilitiesassumednetexcludingcontingentliability" name="Businesscombinationrecognizedidentifiableassetsacquiredgoodwillandliabilitiesassumednetexcludingcontingentliability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_CommitmentToPurchaseUnderGovernmentContracts" name="CommitmentToPurchaseUnderGovernmentContracts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_ContractWithCustomerTimingOfSatisfactionOfPerformanceObligationPaymentPeriod" name="ContractWithCustomerTimingOfSatisfactionOfPerformanceObligationPaymentPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_DeferredIncomeTaxExpenseBenefitBeforeValuationAllowance" name="DeferredIncomeTaxExpenseBenefitBeforeValuationAllowance" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_DeferredTaxAssetLeaseLiabilities" name="DeferredTaxAssetLeaseLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts" name="DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_DeferredTaxLiabilitiesRightOfUseAssets" name="DeferredTaxLiabilitiesRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_DepreciationDepletionAndAmortizationIncludingOtherNonCashAmortization" name="DepreciationDepletionAndAmortizationIncludingOtherNonCashAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_EffectiveIncomeTaxRateReconciliationFederalAndForeignTaxCredits" name="EffectiveIncomeTaxRateReconciliationFederalAndForeignTaxCredits" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_EffectiveIncomeTaxRateReconciliationNondeductibleExecutiveCompensation" name="EffectiveIncomeTaxRateReconciliationNondeductibleExecutiveCompensation" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseAndOtherAdjustments" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseAndOtherAdjustments" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCosts" name="EffectiveIncomeTaxRateReconciliationNondeductibleExpenseTransactionCosts" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_EmployeeRetentionCredit" name="EmployeeRetentionCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_EmployeeRetentionCreditAmountReceived" name="EmployeeRetentionCreditAmountReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_EstimatedPenaltiesToBeIncurredUnderMinimumPurchaseCommitments" name="EstimatedPenaltiesToBeIncurredUnderMinimumPurchaseCommitments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_ExpectingFundAmountUnderGovernmentContract" name="ExpectingFundAmountUnderGovernmentContract" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_FinanceLeaseCost" name="FinanceLeaseCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_FundingEarnedNotYetReceived" name="FundingEarnedNotYetReceived" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_FundingReceivedAmount" name="FundingReceivedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_IncreaseDecreaseInOtherNonCashAmortization" name="IncreaseDecreaseInOtherNonCashAmortization" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_LesseeOperatingAndFinanceLeaseExistenceOfOptionToExtend" name="LesseeOperatingAndFinanceLeaseExistenceOfOptionToExtend" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LesseeOperatingAndFinanceLeasesPeriodOfOptionsToTerminate" name="LesseeOperatingAndFinanceLeasesPeriodOfOptionsToTerminate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LesseeOperatingAndFinancingLeaseExistenceOfOptionToTerminate" name="LesseeOperatingAndFinancingLeaseExistenceOfOptionToTerminate" type="xbrli:booleanItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LesseeOperatingAndFinancingLeaseRemainingLeaseTerm" name="LesseeOperatingAndFinancingLeaseRemainingLeaseTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LongLivedAssets" name="LongLivedAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_NetOfferingProceedsAfterDeductingUnderwritingDiscountAndCommissionAndOfferingExpenses" name="NetOfferingProceedsAfterDeductingUnderwritingDiscountAndCommissionAndOfferingExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_PercentageOfActualPerformanceShareUnitsGranted" name="PercentageOfActualPerformanceShareUnitsGranted" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_PercentageOfReductionOnNonProductionWorkforce" name="PercentageOfReductionOnNonProductionWorkforce" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="osur_PercentageWithheldUnderGovernmentContractsSubjectToValidationTesting" name="PercentageWithheldUnderGovernmentContractsSubjectToValidationTesting" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="osur_ProceedsFromFundingUnderGovernmentContract" name="ProceedsFromFundingUnderGovernmentContract" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_PurchaseOfPatentAndProductRights" name="PurchaseOfPatentAndProductRights" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_PurchaseOfPropertyAndEquipmentUnderGovernmentContracts" name="PurchaseOfPropertyAndEquipmentUnderGovernmentContracts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_ReimbursementOfEngineeringCost" name="ReimbursementOfEngineeringCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_SalesCommissionsAmortizationPeriod" name="SalesCommissionsAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_SeveranceAccrual" name="SeveranceAccrual" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestNumber" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestNumber" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="osur_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpectedToVestWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false"/>
  <xsd:element id="osur_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsPerformanceAdjustmentWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_StockIssuedDuringPeriodSharesVestingOfRestrictedStockAndPerformanceStockUnits" name="StockIssuedDuringPeriodSharesVestingOfRestrictedStockAndPerformanceStockUnits" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_StockIssuedDuringPeriodValueVestingOfRestrictedStockAndPerformanceStockUnits" name="StockIssuedDuringPeriodValueVestingOfRestrictedStockAndPerformanceStockUnits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit"/>
  <xsd:element id="osur_StockOptionPlanGrossExpenseArisingFromEquityBasedCompensation" name="StockOptionPlanGrossExpenseArisingFromEquityBasedCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_UnderwritersOptionExercisablePeriod" name="UnderwritersOptionExercisablePeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_UnderwritersOptionToPurchaseAdditionalShares" name="UnderwritersOptionToPurchaseAdditionalShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_VariableAndShortTermLeaseCost" name="VariableAndShortTermLeaseCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit"/>
  <xsd:element id="osur_ContractualObligationFiscalYearMaturityLineItems" name="ContractualObligationFiscalYearMaturityLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_TransitionCostsLineItems" name="TransitionCostsLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CommonStockOptionsUnvestedRestrictedStockAndUnvestedPerformanceUnitsMember" name="CommonStockOptionsUnvestedRestrictedStockAndUnvestedPerformanceUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ComputerEquipmentAndSoftwareMember" name="ComputerEquipmentAndSoftwareMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CorebiomeIncAndNovosanisNVMember" name="CorebiomeIncAndNovosanisNVMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CorporateBondsMember" name="CorporateBondsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_COVID19Member" name="COVID19Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CovidNineteenAntibodyMember" name="CovidNineteenAntibodyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CryosurgicalSystemsMember" name="CryosurgicalSystemsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_CustomerMember" name="CustomerMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_DiagnosticsMember" name="DiagnosticsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_DiversigenIncMember" name="DiversigenIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_DNAGenotekMember" name="DNAGenotekMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ExpirationPeriodTaxYear2022To2032Member" name="ExpirationPeriodTaxYear2022To2032Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ExpirationPeriodTaxYear2030To2033Member" name="ExpirationPeriodTaxYear2030To2033Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ExpirationPeriodTaxYear2033To2037Member" name="ExpirationPeriodTaxYear2033To2037Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ExpirationPeriodTaxYear2034To2037Member" name="ExpirationPeriodTaxYear2034To2037Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_GenomicsMember" name="GenomicsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_GuaranteedInvestmentCertificatesMember" name="GuaranteedInvestmentCertificatesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_HcvMember" name="HcvMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_HivMember" name="HivMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_LaboratoryServicesMember" name="LaboratoryServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_LeasesInPurchaseCommitmentMember" name="LeasesInPurchaseCommitmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_MaturityOfAvailableForSaleSecurityLessThanOneYearMember" name="MaturityOfAvailableForSaleSecurityLessThanOneYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_MicrobiomeMember" name="MicrobiomeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_MolecularSolutionsMember" name="MolecularSolutionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_NewWarehouseLeaseMember" name="NewWarehouseLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_NonExpiringMember" name="NonExpiringMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_OtherForeignCountriesMember" name="OtherForeignCountriesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_OtherNonProductRevenuesMember" name="OtherNonProductRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_OtherProductAndServicesRevenuesMember" name="OtherProductAndServicesRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_OtherRevenuesMember" name="OtherRevenuesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_PerformanceBasedRestrictedStockMember" name="PerformanceBasedRestrictedStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_PerformanceBasedRestrictedStockUnitMember" name="PerformanceBasedRestrictedStockUnitMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ProductAndServicesMember" name="ProductAndServicesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RangeOneMember" name="RangeOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RangeThreeMember" name="RangeThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RangeTwoMember" name="RangeTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RegisteredRetirementSavingsPlanMember" name="RegisteredRetirementSavingsPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_ResearchAndDevelopmentExpensesAndOtherIncomeMember" name="ResearchAndDevelopmentExpensesAndOtherIncomeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RestrictedStockAwardAndRestrictedStockUnitsMember" name="RestrictedStockAwardAndRestrictedStockUnitsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RiskAssessmentTestingMember" name="RiskAssessmentTestingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RoyaltyIncomeMember" name="RoyaltyIncomeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_StockRepurchaseProgramMember" name="StockRepurchaseProgramMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_TransitionCostsMember" name="TransitionCostsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_UrSureIncMember" name="UrSureIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_RevenueRecognitionByGeographicAreaPolicyTextBlock" name="RevenueRecognitionByGeographicAreaPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueRecognitionByProductPolicyTextBlock" name="RevenueRecognitionByProductPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_ContractualObligationFiscalYearMaturityTable" name="ContractualObligationFiscalYearMaturityTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_TransitionCostsTable" name="TransitionCostsTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="osur_LesseeOperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" name="LesseeOperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LesseeOperatingAndFinancingLeaseTermAndDiscountRateTableTextBlock" name="LesseeOperatingAndFinancingLeaseTermAndDiscountRateTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" name="ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" name="ScheduleOfSupplementalBalanceSheetInformationRelatedToLeasesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_ScheduleOfSupplementalCashFlowInformationRelatedToLeasesTableTextBlock" name="ScheduleOfSupplementalCashFlowInformationRelatedToLeasesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_EmployeeRetentionCreditPolicyPolicyTextBlock" name="EmployeeRetentionCreditPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_LesseeOperatingAndFinancingLeasesTextBlock" name="LesseeOperatingAndFinancingLeasesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_PurchaseObligationFiscalYearMaturityScheduleTableTextBlock" name="PurchaseObligationFiscalYearMaturityScheduleTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueFromContractWithCustomerAssetLiabilityPolicyTextBlock" name="RevenueFromContractWithCustomerAssetLiabilityPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueFromContractWithCustomerMultipleElementArrangementsPolicyTextBlock" name="RevenueFromContractWithCustomerMultipleElementArrangementsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueFromContractWithCustomerSalesOfGoodsPolicyTextBlock" name="RevenueFromContractWithCustomerSalesOfGoodsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueRecognitionFinancingAndPaymentPolicyTextBlock" name="RevenueRecognitionFinancingAndPaymentPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueRecognitionOtherRevenuesPolicyTextBlock" name="RevenueRecognitionOtherRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueRecognitionPracticalExpedientsAndExemptionsPolicyTextBlock" name="RevenueRecognitionPracticalExpedientsAndExemptionsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_RevenueRecognitionServiceRevenuesPolicyTextBlock" name="RevenueRecognitionServiceRevenuesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_SummaryOfGovernmentContractsBalancesIncludedInConsolidatedBalanceSheetTableTextBlock" name="SummaryOfGovernmentContractsBalancesIncludedInConsolidatedBalanceSheetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_SummaryOfGovernmentContractsBalancesIncludedInConsolidatedStatementsOfCashFlowTableTextBlock" name="SummaryOfGovernmentContractsBalancesIncludedInConsolidatedStatementsOfCashFlowTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_SupplementalCashFlowInformationPolicyPolicyTextBlock" name="SupplementalCashFlowInformationPolicyPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="osur_TransitionCostsTextBlock" name="TransitionCostsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
</xsd:schema>
