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  <xs:element id="osur_OtherForeignCountriesMember" abstract="true" name="OtherForeignCountriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_ContractWithCustomerPaymentTypeDomain" abstract="true" name="ContractWithCustomerPaymentTypeDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="osur_RiskAssessmentTestingMember" abstract="true" name="RiskAssessmentTestingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_ExpectingFundAmountUnderGovernmentContract" abstract="false" name="ExpectingFundAmountUnderGovernmentContract" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_PaymentOfReductionInWorkforce" abstract="false" name="PaymentOfReductionInWorkforce" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_FundingReceivedAmount" abstract="false" name="FundingReceivedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_AccruedPropertyAndEquipmentPurchasesUnderGovernmentContracts" abstract="false" name="AccruedPropertyAndEquipmentPurchasesUnderGovernmentContracts" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_MolecularServicesMember" abstract="true" name="MolecularServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_ContractWithCustomerPaymentTypeAxis" abstract="true" name="ContractWithCustomerPaymentTypeAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="osur_TerminationBenefitsTextBlock" abstract="false" name="TerminationBenefitsTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_SummaryOfGovernmentContractsBalancesIncludedInConsolidatedStatementsOfCashFlowTableTextBlock" abstract="false" name="SummaryOfGovernmentContractsBalancesIncludedInConsolidatedStatementsOfCashFlowTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_TerminationBenefitsLineItems" abstract="true" name="TerminationBenefitsLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="osur_CustomerOneMember" abstract="true" name="CustomerOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_OtherRevenuesMember" abstract="true" name="OtherRevenuesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_ConcentrationRiskNumberOfCustomers" abstract="false" name="ConcentrationRiskNumberOfCustomers" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="osur_TerminationBenefitsAbstract" abstract="true" name="TerminationBenefitsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="osur_ReclassificationsAndImmaterialCorrectionOfErrorsPolicyTextBlock" abstract="false" name="ReclassificationsAndImmaterialCorrectionOfErrorsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_IncreaseDecreaseInOtherNonCashAmortization" abstract="false" name="IncreaseDecreaseInOtherNonCashAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_HivMember" abstract="true" name="HivMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_OtherProductAndServicesRevenuesMember" abstract="true" name="OtherProductAndServicesRevenuesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_AccruedExpensesAndOtherCurrentLiabilities" abstract="false" name="AccruedExpensesAndOtherCurrentLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_StockIssuedDuringPeriodSharesVestingOfRestrictedStockAndPerformanceStockUnits" abstract="false" name="StockIssuedDuringPeriodSharesVestingOfRestrictedStockAndPerformanceStockUnits" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="osur_KathleenWeberMember" abstract="true" name="KathleenWeberMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="osur_FundingEarnedNotYetReceived" abstract="false" name="FundingEarnedNotYetReceived" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_SummaryOfOneTimeTerminationBenefitsTableTextBlock" abstract="false" name="SummaryOfOneTimeTerminationBenefitsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" abstract="false" name="ScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_ResearchAndDevelopmentExpensesAndOtherIncomeMember" abstract="true" name="ResearchAndDevelopmentExpensesAndOtherIncomeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_AccruedReductionInWorkforce" abstract="false" name="AccruedReductionInWorkforce" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_ProceedsFromFundingUnderGovernmentContract" abstract="false" name="ProceedsFromFundingUnderGovernmentContract" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_IncreaseDecreaseInCostOfProductsAndServicesSold" abstract="false" name="IncreaseDecreaseInCostOfProductsAndServicesSold" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_ProductAndServicesMember" abstract="true" name="ProductAndServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_TerminationBenefitsTable" abstract="true" name="TerminationBenefitsTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="osur_UpFrontPaymentMember" abstract="true" name="UpFrontPaymentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="osur_HcvMember" abstract="true" name="HcvMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_MolecularProductsMember" abstract="true" name="MolecularProductsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_RevenueFromContractWithCustomerLineItems" abstract="true" name="RevenueFromContractWithCustomerLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="osur_COVID19Member" abstract="true" name="COVID19Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_EstimatedFairValueOnManufacturingEquipmentAndVariousMarketDataPoints" abstract="false" name="EstimatedFairValueOnManufacturingEquipmentAndVariousMarketDataPoints" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_ReimbursementOfEngineeringCost" abstract="false" name="ReimbursementOfEngineeringCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_TerminationBenefits" abstract="false" name="TerminationBenefits" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_OtherNonProductRevenuesMember" abstract="true" name="OtherNonProductRevenuesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_GuaranteedInvestmentCertificatesMember" abstract="true" name="GuaranteedInvestmentCertificatesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_CommonStockOptionsUnvestedRestrictedStockAndUnvestedPerformanceUnitsMember" abstract="true" name="CommonStockOptionsUnvestedRestrictedStockAndUnvestedPerformanceUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_PurchaseOfPropertyAndEquipmentUnderGovernmentContracts" abstract="false" name="PurchaseOfPropertyAndEquipmentUnderGovernmentContracts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_ComputerEquipmentAndSoftwareMember" abstract="true" name="ComputerEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="osur_StockIssuedDuringPeriodValueVestingOfRestrictedStockAndPerformanceStockUnits" abstract="false" name="StockIssuedDuringPeriodValueVestingOfRestrictedStockAndPerformanceStockUnits" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="osur_RevenueFromContractWithCustomerTable" abstract="true" name="RevenueFromContractWithCustomerTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="osur_SummaryOfGovernmentContractsBalancesIncludedInConsolidatedBalanceSheetTableTextBlock" abstract="false" name="SummaryOfGovernmentContractsBalancesIncludedInConsolidatedBalanceSheetTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="osur_CorporateBondsMember" abstract="true" name="CorporateBondsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
</xs:schema>
